I'm really impressed with your digital painting skills, like- damn. You are a master at this.
I really love the atmosphere and how lived in the office feels. It's really fitting and nice to see a 'better' version of Booker's office in contrast to what we see in game. I had to zoom in because you put so much detail into this piece. It's so fantastic. All the little throwbacks and hints to the game itself are great.
Just I have to say, the costume you picked for elizabeth (anna) is kind of a jumbled mess of era's. She's outfitted in a lot of underwear and little outterwear. Along with that, this isn't something the character would likely wear, especially not in front of her father. I'd say go back to the drawingboard clothing wise for Elizabeth. Check out the concept art and it could help you find something sexy (I think that was your intent?) and relatively fitting with the really rich atmosphere you've built up in this piece.